Codeine
CAS Number:
76-57-3
Batch Molecular Formula:
C18H21NO3
Batch Molecular Weight:
299.4 g·mol
Physical Appearance:
Codeine appears as colorless to white crystalline solid or white powder
Solubility:
Soluble in Water
Storage:
Store at RT
Codeine API is an opioid analgesic used primarily for the management of mild to moderate pain and, in certain formulations, for the relief of cough. Codeine works by acting on opioid receptors in the central nervous system, helping reduce the perception of pain and suppressing the cough reflex. As an opioid, codeine has potential for misuse, dependence, and respiratory depression and is regulated as a controlled substance in many countries.
Codeine formulations are available in several dosage forms, including immediate-release tablets, extended-release tablets, oral solutions, and syrups. Formulations and approved uses may vary depending on the country and applicable regulatory requirements.
1. Immediate-Release Formulations
Pain Management: Used for the management of mild to moderate pain when clinically appropriate.
Oral Solutions and Syrups: May be used for pain or cough relief depending on the specific formulation and indication.
Administration: Dosing and frequency should be determined by a healthcare professional based on the indication, patient response, and applicable prescribing requirements.
2. Extended-Release Formulations
Extended-Release Tablets: Designed to provide prolonged release of codeine for specific clinical applications.
Cough Management: Certain extended-release formulations may be used for cough relief where approved.
3. Codeine Combination Products
Codeine may be combined with other active pharmaceutical ingredients (APIs), including non-opioid analgesics, to provide additional therapeutic effects.
Axim Pharma – Codeine API Manufacturer & Contract Manufacturer in India
Axim Pharma is a trusted Codeine API manufacturer and contract manufacturer in India, serving pharmaceutical customers across China, Turkey, Hong Kong, the USA, Europe, and other international markets. We offer custom manufacturing, bulk API supply, competitive pricing, and seamless logistics tailored to pharmaceutical requirements.
Partner with Axim Pharma for high-quality Codeine API production, custom synthesis, bulk supply, and global distribution, supporting consistent quality and compliance with applicable regulatory requirements.
Contact our sales team today for personalized quotations and efficient delivery solutions.
Effects
1. Primary Uses
Pain Management: Codeine is used as an opioid analgesic for the management of mild to moderate pain in appropriate clinical settings.
Cough Relief: Certain codeine formulations are used as antitussives to suppress cough.
Combination Therapy: Codeine may be formulated with other active ingredients to support pain management or address multiple symptoms.
2. Mechanism of Action
Codeine acts primarily through the opioid system in the central nervous system. It is metabolized in the body to morphine, which contributes to its analgesic effects. Codeine also suppresses the cough reflex through its action on the central nervous system.
Usage
1. Therapeutic Effects
Pain Relief: Reduces the perception and emotional response to pain.
Cough Suppression: Certain formulations can reduce the frequency and intensity of coughing.
Central Nervous System Effects: May produce relaxation and sedation as part of its opioid activity.
2. Common Side Effects
Drowsiness or Sedation: May cause sleepiness and reduced alertness.
Dizziness: May affect balance and coordination.
Nausea and Vomiting: Gastrointestinal symptoms may occur, particularly during initial treatment.
Constipation: Reduced gastrointestinal motility is a common opioid-related effect.
Dry Mouth: May occur during treatment.
Sweating: Increased sweating can occur in some individuals.
3. Serious Risks
Respiratory Depression: Codeine can slow breathing, particularly at higher doses or when combined with other central nervous system depressants.
Dependence and Withdrawal: Prolonged use may lead to physical dependence, and abrupt discontinuation can cause withdrawal symptoms.
Misuse and Addiction: Codeine is an opioid with potential for misuse and addiction.
Overdose: Excessive opioid exposure can cause severe respiratory depression, loss of consciousness, and potentially fatal overdose.
Drug Interactions: Combining codeine with alcohol, opioids, sedatives, or other central nervous system depressants can increase the risk of serious adverse effects.
Disclaimer
Products falling in to controlled substance category / list of schedule drugs shall be exported directly from the manufacturer principals only against receipt of original import permission issued by concerned authorities of the importing country. Products protected by valid patents are not offered for sale in countries where the sale of such products constitutes a patent infringement and its liability is at buyer’s risk. Most OTC drugs are not reviewed and approved by FDA, however, they may be marketed if they comply with applicable regulations and policies. FDA has not evaluated whether this product complies. This is only for study not for any Human / Veterinary use. (Condition Apply)* Axim Pharmaceutical India warns the buyers / importers not to use/sell/procure any goods to achieve a product which might be knowingly causing an infringement / controlled / banned drugs. Axim Pharmaceutical India is not responsible or liable for the same.
