Lorazepam
CAS Number:
846 - 49 - 1
Batch Molecular Formula:
C15H10Cl2N2O2
Batch Molecular Weight:
321.16 g·mol
Physical Appearance:
White Powder
Solubility:
Soluble in Water
Storage:
Store at RT
Lorazepam API (Ativan) is a benzodiazepine medication used for the short-term relief of severe anxiety, anxiety-associated insomnia, and pre-anesthesia sedation. It works by slowing excessive activity in the central nervous system to produce calming and sedative effects. Lorazepam is also used in acute clinical settings for status epilepticus and may be used for alcohol withdrawal and chemotherapy-associated nausea and vomiting.
Lorazepam formulations can be categorized based on their medical applications and clinical uses:
1. Medical Pharmaceutical Applications
Anxiety Disorders: Used for the short-term management of severe anxiety symptoms.
Anxiety-Associated Insomnia: Used to manage difficulty sleeping associated with anxiety.
Status Epilepticus: Used in acute clinical situations to help control severe seizures.
Pre-Surgery Sedation: Used as premedication to reduce anxiety, produce sedation, and provide anterograde amnesia associated with medical procedures.
Alcohol Withdrawal: May be used to manage certain symptoms associated with acute alcohol withdrawal.
Chemotherapy-Associated Nausea: May be used as part of clinical management for chemotherapy-associated nausea and vomiting.
Other Clinical Applications: May be used in specific circumstances for rapid tranquilization of severely agitated patients and psychogenic catatonia.
Axim Pharma – Lorazepam API Manufacturer & Contract Manufacturer in India
Axim Pharma is a trusted Lorazepam API manufacturer and contract manufacturer in India, serving pharmaceutical customers across China, Turkey, Hong Kong, the USA, Europe, and other international markets. We offer custom manufacturing, bulk API supply, competitive pricing, and seamless logistics tailored to pharmaceutical requirements.
Partner with Axim Pharma for high-quality Lorazepam API production, custom synthesis, bulk supply, and global distribution, supporting consistent quality and compliance with applicable regulatory requirements.
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Effects
1. Therapeutic Effects
Anxiolytic Effect: Helps reduce severe anxiety, tension, and nervous distress.
Sedative Effect: Produces a calming and sedative effect by reducing central nervous system activity.
Anticonvulsant Effect: Helps suppress abnormal neuronal activity associated with certain seizures.
Amnestic Effect: Can produce anterograde amnesia, which is useful in certain preoperative and procedural settings.
Muscle Relaxation: May contribute to reduced muscle tension through its central nervous system activity.
2. Common Side Effects
Drowsiness and Sedation: May cause sleepiness and reduced alertness.
Dizziness and Lightheadedness: May affect balance and coordination.
Fatigue: Can cause tiredness and reduced energy.
Muscle Weakness: May occur as a result of its central muscle-relaxant effects.
Calm or Relaxed Feeling: Its anxiolytic and sedative effects may produce a pronounced sense of calm.
Usage
1. Primary Uses
Anxiety Management: Used for the short-term treatment of severe anxiety symptoms.
Insomnia: Used for sleep difficulties associated with anxiety.
Seizure Management: Used in acute medical settings for the treatment of status epilepticus.
Preoperative Sedation: Used before certain procedures to reduce anxiety and produce sedation and amnesia.
Alcohol Withdrawal: Used in appropriate clinical settings to manage symptoms associated with alcohol withdrawal.
Chemotherapy-Associated Nausea and Vomiting: May be used as part of supportive treatment under medical supervision.
2. Mechanism of Action
Lorazepam enhances the activity of GABA at GABA-A receptors in the central nervous system. By increasing inhibitory neurotransmission, it reduces excessive neuronal activity and produces its anxiolytic, sedative, anticonvulsant, and muscle-relaxant effects.
Disclaimer
Products falling in to controlled substance category / list of schedule drugs shall be exported directly from the manufacturer principals only against receipt of original import permission issued by concerned authorities of the importing country. Products protected by valid patents are not offered for sale in countries where the sale of such products constitutes a patent infringement and its liability is at buyer’s risk. Most OTC drugs are not reviewed and approved by FDA, however, they may be marketed if they comply with applicable regulations and policies. FDA has not evaluated whether this product complies. This is only for study not for any Human / Veterinary use. (Condition Apply)* Axim Pharmaceutical India warns the buyers / importers not to use/sell/procure any goods to achieve a product which might be knowingly causing an infringement / controlled / banned drugs. Axim Pharmaceutical India is not responsible or liable for the same.
